DEPARTMENT NAME
Department of Otolaryngology, Oncology, Audiology and Phoniatrics

CONTACT DETAILS FOR HEAD OF DEPARTMENT
Prof. Jurek Olszewski, MD, PhD
[email protected]

Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics – IInd Chair Otolarynglogy
ul. Żeromskiego 113
90-549 Lodz, Poland

TEAM MEMBERS
Prof. Jurek Olszewski, MD, PhD
Jarosław Miłoński MD, PhD
Piotr Pietkiewicz MD, PhD
Marzena Mielczarek MD, PhD

SHORT DESCRIPTION OF RESEARCH ACTIVITY

The projects include the evaluation of the association of DNA repair XRCC3 C722T and RAD51 G135C gene polymorphisms and the risk of head and neck cancers.

Another research project involves research on inverted papillomas as a unique group of locally aggressive, benign tumors within the nasal cavity and paranasal sinuses.

The results of these studies suggest that the presence of -5 / G SNP in the MT2A gene can influence a gene expression specific for the allele, and an accumulation of toxic metals in the nasal pharynx and paranasal sinuses

DEPARTMENTAL ACHIEVEMENTS: PROJECTS AND PAPERS

1. Starska K., Olszewski J. i wsp.: The −5 A/G single-nucleotide polymorphism in the core promotor region of MT2Aand its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer. Toxicol Pharmacol., 2014; 280: 256.
2. Miłoński J. i wsp.: DNA damage and oxidant-antioxidant status in blood of patients with head and neck cancer.DNA Cell Biology, 2015 ;34(30).
3. Starska K., Olszewski J. i wsp.: Metallothionein. 2A core promoter region genetic polymorphism and its impact onthe risk, tumor behavior, and recurrences of sinonasal inverted papilloma. Tumor Biol., 2015; 36(11).
4. Mielczarek M., Olszewski J. i wsp.: An increase in alpha band frequency in resting state EEG after electricalstimulation of the ear in tinnitus patients. Frontiers Neuroscience, 2016;10.
5. Mielczarek M., Olszewski J. i wsp.: Exome 4, 5, 12 sequencing in patients with postlingual sensorineural hearingloss accompanied by vestibular lesion. Arch Med Science, 2018;14(3).