DEPARTMENT NAME
Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy

CONTACT DETAILS FOR HEAD OF DEPARTMENT
Prof. Elżbieta Mikiciuk-Olasik
[email protected]
+ 48 42 677 92 90

Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy
ul. Muszynskiego 1

90-151 Lodz, Poland

TEAM MEMBERS
Prof. Elżbieta Mikiciuk-Olasik
Dr hab. prof. Paweł Szymański
Dr hab. prof. Joanna Sikora
Magdalena Markowicz-Piasecka, PhD
Paulina Olszewska, PhD
Elżbieta Żurek, PhD
Ireneusz Bilichowski, PhD
Kamila Czarnecka, MSc

SHORT DESCRIPTION OF RESEARCH ACTIVITY
Research in the Laboratory of Bioanalysis is focused on the biocompatibility and bioactivity assessment of new compounds and natural substances using in vitro methods (human blood and cell culture models). Research in the Laboratory of Radiopharmacy is focused on the use of new radiopharmaceuticals as tools for diagnosis of Alzheimer’s disease and multifunctional agents for its treatment.

Keywords:
biocompatibility, in vitro, overall potential of haemostasis, coagulation, AChE inhibitors, Alzheimer’s disease

DEPARTMENTAL ACHIEVEMENTS: PROJECTS AND PAPERS

Project: In search of novel metformin prodrugs. Biocompatibility and pharmacokinetic in vitro studies– with University of Eastern Finland.

Project: New hydrids of tetrahydroacridine derivatives as an acetylocholinesterase with multifunctional activity.

1. Metformin and its sulfenamide prodrugs inhibit human cholinesterase activity. Oxid Med Cell Longev 2017
2. Metformin – a future therapy for neurodegenerative diseases. Pharm Res 2017
3. Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer’s disease treatment. Bioorg Chem, 2017
4. Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling. Tumor Biol, 2017
5. Synthesis, physicochemical and biological studies of technetium-99m labeled tacrine derivative as a diagnostic tool for evaluation of cholinesterase level, Bioorg Med Chem, 2017